Haptoglobin halts hemoglobin’s havoc
نویسندگان
چکیده
منابع مشابه
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متن کاملBinding of acellular, native and cross-linked human hemoglobins to haptoglobin: enhanced distribution and clearance in the rat.
It is well established that hemoglobin resulting from red cell lysis binds to haptoglobin in plasma to form a complex. The increased molecular size precludes its filtration by the kidneys, redirecting it toward hepatocellular entry. Chemically cross-linked hemoglobins are designed to be resistant to renal excretion, even in the absence of haptoglobin. The manner in which binding to haptoglobin ...
متن کاملCD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin.
CD163 mediates the internalization of hemoglobin-haptoglobin (Hb-Hp) complexes by macrophages. Because Hp binding capacity is exhausted during severe hemolysis, an Hp-independent Hb-clearance pathway is presumed to exist. We demonstrate that Hb interacts efficiently with CD163 in the absence of Hp. Not only is Hb internalized into an endosomal compartment by CD163 as a result of active receptor...
متن کاملmodified hemoglobins in the absence of haptoglobin CD 163 is the macrophage scavenger receptor for native and chemically
word count: 198 text word count: 5414 Acknowledgments: We thank Dr. Stephanie Hiss (University of Bonn, Germany) for bovine Hp determination. Supported by the Foundation for Research at the Medical Faculty, University of Zurich (DS) and by the Hartmann-Muller Foundation (DS). Contributions: DJS: designed and performed research, wrote the paper; CAS: performed research; PWB: performed research; ...
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THE PHENOTYPIC CHARACTERIZATION of obstructive sleep apnea (OSA) continues to unfold. Recent studies provide evidence that this syndrome has the potential to disturb cardiovascular, neurological, and endocrine homeostatic processes (1, 6, 8, 9). Li et al. (5) present convincing evidence that long-term exposure to hypoxia-reoxygenation, modeling oxygenation patterns of severe sleep apnea, impair...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2009
ISSN: 0021-9738
DOI: 10.1172/jci40258